Sequence Analysis and Topology

The topology of a protein structure is a highly simplified description of its fold that includes only the sequence of secondary structure elements and their approximate spatial positions and orientations. This information can be represented as a two-dimensional protein topological diagram known as a TOPS cartoon. These illustrations are helpful for comprehending specific folds and making similarities between folds.

Sequence analysis is an all-encompassing phrase for the computational examination of a DNA, RNA, or peptide sequence in order to extract information about its properties, biological function, structure, and evolution. To conduct efficient sequence analysis, it is necessary to first comprehend the origin of the data, i.e., the various experimental techniques utilised to determine the biological sequence. An important use of bioinformatics is sequence analysis.  Several sequence alignment tools, such as BLAST and FASTA Clustal, can be used to examine single or multiple sequences for similarity and identity.