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Drug Designing and Biomarkers

Drug design, often known as rational drug design or rational design, is the creative process of discovering new medications based on understanding of a biological target. Typically, the medicine is a tiny organic molecule that activates or inhibits the action of a biomolecule, such as a protein, resulting in a therapeutic benefit for the patient. Drug design commonly but not necessarily relies on computer modelling approaches. This form of modelling is also known as computer-aided drug design. Secondly, drug design that relies on the three-dimensional structure of the bimolecular target is called structure-based drug design. In addition to small molecules, biopharmaceuticals such as peptides and therapeutic antibodies are becoming an increasingly important class of medications. Computational approaches have also been created for the purpose of improving the affinity, selectivity, and stability of protein-based treatments.

A biological molecule found in blood, other body fluids, or body tissues that is a sign of a normal or abnormal condition, or a disease. A biomarker can be used to see how well a treatment for a disease or condition works on the body.

A good biomarker has certain qualities that make it a good choice for checking on a certain disease. In an ideal world, a marker should have the following:

•   Safe and easy to measure
•   It doesn't cost much to follow up.
•   Changeable based on treatment
•   Consistent no matter what gender or race you are

Serious diseases like diabetes and cardiovascular disease can be predicted with the help of biomarkers.

For the purpose of cancer detection, screening, diagnosis, treatment, and monitoring, the principles of biomarkers will be employed.

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